Hunters devote themselves to accomplishing hazardous tasks, all from traversing the world's uncharted territories to locating rare items and monsters. Before becoming a Hunter, one must pass the Hunter Examination—a high-risk selection process in which most applicants end up handicapped or worse, deceased.

Ambitious participants who challenge the notorious exam carry their own reason. What drives 12-year-old Gon Freecss is finding Ging, his father and a Hunter himself. Believing that he will meet his father by becoming a Hunter, Gon takes the first step to walk the same path.

During the Hunter Examination, Gon befriends the medical student Leorio Paladiknight, the vindictive Kurapika, and ex-assassin Killua Zoldyck. While their motives vastly differ from each other, they band together for a common goal and begin to venture into a perilous world.