Madara, nicknamed "Nyanko-sensei," runs into two young children when he gets separated from his temporary owner Takashi Natsume. Unequipped to handle kids, Nyanko-sensei tries to wriggle his way out; but fearing for their safety around the ravenous forest youkai, he decides to escort the siblings to safety. However, even for an all-powerful youkai such as Nyanko-sensei, dealing with the playful and overly curious nature of children can prove to be an exhausting challenge.