Patty Lowell—the lost heir of a prestigious family—is found at an orphanage, and J.D. Morrison brings her to his acquaintance Dante, the owner of a business called "Devil May Cry." Dante takes on so-called "odd jobs," and at Morrison's request, he agrees to become a bodyguard for Patty. Begrudgingly, he sets out to deliver Patty to her family, though he is a bit annoyed with a job that essentially amounts to babysitting.

While Dante seems like a lazy good-for-nothing, he is actually a prolific demon hunter, which comes in handy when demons begin pursuing Patty. Soon enough, Dante realizes that there is more to this case than meets the eye, and he makes use of his particular skill set in order to keep Patty safe.