In a futuristic world, the Maruhage Empire is a militant organization out to steal everyone's hair, and thus their freedom. But a brave man with an afro of gold and nose hairs of steel stands up against their tyranny. Bobobo-bo Bo-bobo, trained in the ways of hair, rescues a teenager named Beauty from the grunts of the Maruhage Empire. Together, they start on a journey to defeat Emperor Tsuru Tsurulina IV. As Bo-bobo meets new friends and battles foes along the way, so too does he begin his quest to save all the hairs of the world!

Light-hearted and comical, Bobobo-bo Bo-bobo details a wacky adventure in which Bo-bobo and his companions fight all sorts of villains and deviants within the Maruhage Empire, all the while having a fun and exciting adventure.