One hundred miles south of Los Angeles, a reckless biker named Marcia and her newfound acquaintance Noera crash their vehicles after getting caught in the explosion of a semi truck. In the resulting confusion, Marcia manages to sneak off with a briefcase containing a mysterious dark orb. When Marcia and Noera touch it, they experience a vision of Death Valley. Taking this as a sign that the ball needs to be brought to Death Valley, the pair set out on the road, chasing their version of the American Dream, all while evading those who seek to take the elusive object back from them.

Director Mizuho Nishikubo intended for California Crisis: Tsuigeki no Juulka's story to be concluded in a sequel movie, but his studio went out of business shortly after the original video animation was released.