In a post-apocalyptic world overrun by alien-crafted "Machine Lifeforms," humanity is preparing for its last stand. Forced to retreat to the Moon for safety, humans are pinning their hopes on a group of man-made androids known as YoRHa soldiers. Led by the all-purpose battle android YoRHa 2-gou B-gata "2B," the group will fight to take control of the Earth back from its invaders.

As war against the machines rages on, the YoRHa slowly begin to see the first shards of truth underlying the brutal conflict. Facing the harsh reality before her, the unwavering warrior 2B starts to question her very existence and just how much she must sacrifice for the sake of humanity.