Kenjaku, the one known as Noritoshi Kamo and most recently as Suguru Getou, has initiated the next step in his destructive, thousand-year plan of ordinary humans' evolution and eventual eradication. The jujutsu world higher-ups reinstate 15-year-old Yuuji Itadori's execution, as Satoru Gojou is incapacitated as a result of Kenjaku's master plan in Shibuya. While Yuuji is unaware of this, he patrols the abandoned Tokyo streets with Chousou, exterminating any and all cursed spirits in his way.

Meanwhile, the bigoted and arrogant Naoya Zenin's pride takes a hit when Megumi Fushiguro is selected as the Zenin Clan's next head. To draw out Megumi and eliminate him, he goes after Yuuji—but Yuuta Okkotsu is set on being Yuuji's executioner. Kenjaku's "Culling Game"—a rigorous battle royale spanning throughout Japan and forcing the jujutsu competitors to kill each other—is set in motion, and the young jujutsu sorcerers join the fray to settle old scores, free Gojou, and liberate the jujutsu world from the threat that is Kenjaku.