Kaoruko "Chaos" Moeta is a young manga artist who is down on her luck. She wants to draw manga about high school girls, but her storyboards are bland, her art uninspired, and her premises weak. Her concerned, exasperated editor comes up with an idea: push Chaos to be more social. So, by her recommendation, Chaos moves into a dormitory for female manga artists. She soon meets the other residents: Tsubasa Katsuki, a shounen manga artist; Ruki Irokawa, who draws erotic manga popular with women; and Koyume Koizuka, a shoujo artist who, like Chaos, has yet to be serialized. Quickly striking up a friendship with these girls, Chaos finds new inspiration for her manga and continues to grow her creativity.

Comic Girls is a showcase of the daily lives of these manga artists. Will Chaos finally be able to make her debut and become serialized? None of the girls know, but they will all do their best to help each other become the best artists they can be.