To the average person, psychic abilities might seem a blessing; for Kusuo Saiki, however, this could not be further from the truth. Gifted with a wide assortment of supernatural abilities ranging from telepathy to x-ray vision, he finds this so-called blessing to be nothing but a curse. As all the inconveniences his powers cause constantly pile up, all Kusuo aims for is an ordinary, hassle-free life—a life where ignorance is bliss.

Unfortunately, the life of a psychic is far from quiet. Though Kusuo tries to stay out of the spotlight by keeping his powers a secret from his classmates, he ends up inadvertently attracting the attention of many odd characters, such as the empty-headed Riki Nendou and the delusional Shun Kaidou. Forced to deal with the craziness of the people around him, Kusuo comes to learn that the ordinary life he has been striving for is a lot more difficult to achieve than expected.

Saiki Kusuo no Ψ-nan aired weekly from Monday to Friday short 5 minute episodes in the morning block until November 4, 2016. A full episode every Sunday night followed the morning block short, but later became the main broadcast time. The series was later recompiled as 24 regular-length episodes on streaming and home media.