After escaping certain death, Kei Nagai and his new companion Kou Nakano plot revenge on Satou, their fellow Ajin who is hellbent on world domination. As Satou embarks on a string of public executions, the human race rushes to come up with a solution to stop the immortal villain.

Kei discovers unlikely allies in the form of two former adversaries: high-ranking government official Yuu Tosaki, whose extensive research on Ajin gives him a tactical advantage in the fight against Satou, and Tosaki's Ajin assistant Izumi Shimomura. As his faction continues to gather allies, Kei races against time to put a stop to Satou's crusade before it brings about an end to civilization as he knows it.