In a world filled with strange yet majestic creatures known as Pokémon, a new adventure begins! Hailing from the pristine region of Paldea, the timid Liko travels to the Kanto region to attend the Indigo Academy and become a Pokémon trainer—a person who forms relationships with Pokémon and trains them to participate in battles. Soon, Liko acquires Nyahoja, a fickle Grass-type cat Pokémon, as her first partner.

Prior to Liko's transfer to Kanto, her grandmother gives her a uniquely patterned and gleaming pendant as a protective charm. However, an enigmatic organization—The Explorers—seems to know a secret about the pendant and nearly succeeds in stealing it from Liko. Fortunately, she is rescued by the Rising Volt Tacklers, a group of adventurers led by a Lizardon-riding trainer named Friede.

After a series of encounters with The Explorers, Liko decides to join Friede's team, accompanying him and his crew members on a grand journey across the regions. Along the way, they aim to unravel not only the mysteries of the world of Pokémon, but also the power that resides within her pendant.

Pokemon (2023) features elements and settings from the 2022 Nintendo Switch games Pokémon Scarlet and Violet by Game Freak.