Two years after saving the world from a cataclysmic event, the members of the activist organization Avalanche have gone their separate ways. Tifa Lockhart opens a new bar, and her childhood friend Cloud Strife starts up a motorcycle-based courier service. Although most of their former allies have fallen out of touch, Cloud and Tifa live in fragile peace with their two young wards Marlene and Denzel.

Their life together begins to crumble as a contagious plague and overwhelming grief pull Cloud away from his newfound family. While distancing himself through his work, Cloud is attacked by three silver-haired figures in black uniforms who bear a passing resemblance to his bitter rival, Sephiroth. As the antagonistic trio stalks Cloud and brings harm to his loved ones, the former mercenary struggles against his own demons while fighting to protect his family and prevent the will of Sephiroth from returning to the planet.