Yobi, The Five Tailed Fox revolves around a kumiho, a nine-tailed fox that can assume different forms including human. Kumiho are familiar figures in Korean folk tales, and they are usually depicted as magical creatures that take female form to lure and prey on humans. This time, however, our protagonist is a young, kind-hearted fox with only five tails, instead of nine.

After losing her family to fox hunters, five-tailed Yobi lives in the forest with some shipwrecked aliens, far away from the humans. When one of her alien friends gets captured by a villager, Yobi has no choice but to adventure into the human world to rescue him. At the village, Yobi meets many humans, including Geum Yee who studies at a school for maladjusted children. Interested in Geum Yee, Yobi joins the students and revels in the fun of human life, but both a fox hunter and a mysterious shadow man are on her trail.