Pokémon are peculiar creatures with a vast array of different abilities and appearances; many people, known as Pokémon trainers, capture and train them, often with the intent of battling others. Young Satoshi has not only dreamed of becoming a Pokémon trainer but also a "Pokémon Master," and on the arrival of his 10th birthday, he finally has a chance to make that dream a reality. Unfortunately for him, all three Pokémon available to beginning trainers have already been claimed and only Pikachu, a rebellious Electric-type Pokémon, remains. However, this chance encounter would mark the start of a lifelong friendship and an epic adventure!

Setting off on a journey to become the very best, Satoshi and Pikachu travel across beautiful, sprawling regions with their friends Kasumi, a Water-type trainer, and Takeshi, a Rock-type trainer. But danger lurks around every corner. The infamous Team Rocket is always nearby, seeking to steal powerful Pokémon through nefarious schemes. It'll be up to Satoshi and his friends to thwart their efforts as he also strives to earn the eight Pokémon Gym Badges he'll need to challenge the Pokémon League, and eventually claim the title of Pokémon Master.

Due to various controversies and discussions during the series' original broadcast, several episodes were banned or simply not included in the official physical releases of the show. Due to this, the current official Pokémon Anime Guide lists the episode count without two original episodes as 274.

As the very first anime adaptation of the franchise, this show is officially referred to as either "The Original Pokémon Anime Series" or simply "The First Season of the Pokémon Anime".