Lain Iwakura, an awkward and introverted fourteen-year-old, is one of the many girls from her school to receive a disturbing email from her classmate Chisa Yomoda—the very same Chisa who recently committed suicide. Lain has neither the desire nor the experience to handle even basic technology; yet, when the technophobe opens the email, it leads her straight into the Wired, a virtual world of communication networks similar to what we know as the internet. Lain's life is turned upside down as she begins to encounter cryptic mysteries one after another. Strange men called the Men in Black begin to appear wherever she goes, asking her questions and somehow knowing more about her than even she herself knows. With the boundaries between reality and cyberspace rapidly blurring, Lain is plunged into more surreal and bizarre events where identity, consciousness, and perception are concepts that take on new meanings.

Serial Experiments Lain won the Excellence Prize in the 1998 Japan Media Arts Festival. It has been subject to commentary in the literary and academic worlds such as the Asian Horror Encyclopedia and The Problem of Existence in Japanese Animation by the American Philosophical Society.