When private detective Gokuu Fuurinji is contacted by Ryoko Kadoma about locating her missing brother, Ryuu, Gokuu knows this is no normal case. Ryuu was the victim of a cruel genetic experiment and will soon become a mindlessly violent superbeing without proper treatment. Armed with the world's most powerful supercomputer implanted in his left eye, the detective sets out to locate the missing boy. But as the case becomes more complex, Gokuu is forced to question whether it is possible to save Ryuu or if he will have to kill him before he fully transforms.

Midnight Eye: Gokuu II was released on DVD and Blu-ray by Discotek Media on July 25, 2017, and October 31, 2023, respectively.