In the year 19XX, after being betrayed and left for dead, bravehearted warrior Kenshirou wanders a post-apocalyptic wasteland on a quest to track down his rival, Shin, who has kidnapped his beloved fiancée Yuria. During his journey, Kenshirou makes use of his deadly fighting form, Hokuto Shinken, to defend the helpless from bloodthirsty ravagers. It is not long before his exploits begin to attract the attention of greater enemies, like warlords and rival martial artists, and Kenshirou finds himself involved with more than he originally bargained for.

Faced with ever-increasing odds, the successor of Hokuto Shinken is forced to put his skills to the test in an effort to take back what he cares for most. And as these new challenges present themselves and the battle against injustice intensifies, namely his conflict with Shin and the rest of the Nanto Seiken school of martial arts, Kenshirou is gradually transformed into the savior of an irradiated and violent world.