At Ouran High School, an academy where only the children of the rich and powerful attend, there exists a club consisting of the most elite of the student body: the legendary Host Club. Within the club's room, six beautiful, bored boys spend their time entertaining equally beautiful and bored girls.

Haruhi Fujioka, a poor scholarship student, has no interest in the Host Club—until she breaks a valuable vase in their clubroom. After being mistaken for a boy, Haruhi is forced by Kyouya Ootori to work for the Host Club to repay her debt. Tamaki Suou, the princely leader of the club, eagerly takes her under his wing to teach her the ways of the host.

Things, however, are never quite so simple with the Host Club around. Even the most mundane events can turn into huge spectacles with the likes of prankster twins Hikaru and Kaoru Hitachiin, stoic Takashi Morinozuka, and sweet Mitsukuni "Hunny" Haninozuka. The crazy adventures of the Host Club are just beginning, and Haruhi must learn how to survive in the glitzy world of the hosts.

Note: The final volume contains a special bonus chapter where the group travels to Spain.

Ouran Koukou Host Club was published in English as Ouran High School Host Club by VIZ Media under the Shojo Beat imprint from July 5, 2005, to June 5, 2012. An 18-volume boxed set including an exclusive notepad featuring the character's art was later released. It was also published in Polish by Japonica Polonica Fantastica from October 2009 to September 2013.

The series was adapted into several drama CDs, which were given to LaLa magazine applicants. It was also adapted into a live-action TV series with a live-action film sequel; the former aired from July 22, 2011, to September 30, 2011, and the latter premiered on March 17, 2012. Three Japanese musical adaptations of the manga were performed in 2022 and 2023.