Sho and his friend, Tetsuro, stumble upon a strange orb-like mechanism, the Guyver Unit, in the woods. It physically bonds with Sho and turns him into the alien soldier, Guyver. His mission is to protect the Guyver Unit from the Japanese corporation known as Chronos. They are after it and two other units just like it. To retrieve the object, they send out vicious monsters known as Zoanoids. So no one is safe in Sho's life; not even himself.

Kyoushoku Soukou Guyver was published in English as Bio-Booster Armor Guyver in comic book format as part of the VIZ Manga Heroes series for 44 issues, running from October 1993 to April 1997. It had seven volumes published by VIZ Media from August 5, 1995 to January 28, 1998. Chuang Yi released the manga in English in Singapore as well.