At the dawn of the 17th century, at the end of the era of civil wars, in a world of chaos, the epic Battle of Sekigahara was joined. One man emerged from the largest battle ever fought on Japanese soil; a terrible warrior of unspeakable power, he was nicknamed 'the unconquerable.'

Kyoshiro is a peaceful medicine peddler who harbors the soul of an assassin. He accompanies a young bounty hunter across Japan in search of a murderer and on a quest to discover the terrible secret of his own identity.

Tokyopop published the first 34 volumes of Samurai Deeper Kyou in English from June 10, 2003 to April 7, 2009. The remaining volumes were published in two-in-one omnibuses by Del Rey from December 15, 2009 to June 22, 2010.