Shinichi Chiaki, the perfectionist son of a famous pianist, is in his fourth year at Momogaoka College of Music, hoping to achieve his secret dream of being a conductor. His admiration for his father led him to pursue a career in music. As much as he wants to return to Europe, his phobia of flying traps him in Japan where he now lives.

One night, he passes out, and ends up being taken in by Megumi "Nodame" Noda. Upon first glance, Nodame is a talented pianist, but she is also slobbish and eccentric. What's even worse is that she is his neighbor and he ends up forced to work with her. Though it sounds like a recipe for disaster, Chiaki is drawn to this girl who makes him remember the love for music he once held. Just what does the future hold for this musical duo?