Although the rounin Souichirou Senou quickly discovers that most of his new neighbors in the Katagi Apartments do not trust him, his childlike wonder at the world around him allows him to strike up a friendship with the carpenter's son, Kankichi. With Kankichi's help, Souichirou begins to establish a life in Edo's tenements and exchanges his longtime sword Kunifusa for a bamboo blade, due to his newfound desire to refrain from violence.

Unfortunately for Souichirou, avoiding conflict in Edo is not always possible. Before long, Souichirou finds himself stalked by the brutal assassin Shinnosuke Kikuchi, who delights in butchering anyone caught between him and his target. Each time Souichirou must step forward to defend himself or the people of the tenements, he reawakens the intense bloodlust of his younger days and resurrects memories he would much rather forget.

Takemitsuzamurai was published in Spanish by Ediciones Glénat from October 2009 to December 2012.

The manga won the Excellence Prize in the manga division at the 11th Japan Media Arts Festival Awards in 2007, along with the Grand Prize at the 15th Tezuka Osamu Cultural Prize in 2011. It was nominated for Best Comic at the 2012 Angoulême International Comics Festival.