The elite all-girls Wild's Private High School has bred some of the strongest and most renowned martial artists in the world. To help foster these skills, the school hosts the Wild's League, a brutal martial arts tournament where only the strongest fighters prevail. Reigning above all other students is the current champion "Queen," a beautiful S-Class mixed martial artist named Yoon In Gyi, who has mastered various forms of fighting.

When Wild's High breaks its 42-year-old tradition of female exclusivity and allows male applicants, only one is desperate enough to try: the weak and impoverished Song Jae Gu, who is granted a full scholarship. After a meeting with the cute taekwondo practitioner Choi Dal Dal, the boisterous boxer Lee Moon Young, and Queen in a tense confrontation, Jae Gu soon realizes that he must quickly learn to fend for himself in this dangerous battlefield.

Girls of the Wild's has been published in Japan as Shoujo the Wild's (少女・ザ・ワイルズ) by Futabasha since August 28, 2015.