While the gold rush takes Europe by storm, a young Jonathan Joestar lives a life of luxury with his father at their estate in Liverpool, England. Jonathan, known by his peers as JoJo, spends his days playing the part of a gentleman and living a carefree life. However, those peaceful days soon came to an end when Dio Brando intrudes upon him.

Dio is a young boy from London who is adopted into the Joestar family due to a debt Jonathan's father owed to Dio's father. While Jonathan is receptive towards having a new brother, Dio schemes against the Joestars in order to inherit the fortune. As Dio's schemes get out of hand, Jonathan is forced to confront him once and for all.

Thus begins the story of the Joestar bloodline, as Jonathan matures with and eventually combats his adoptive brother while encountering bizarre new friends and foes.

A 17-volume kanzenban version dubbed as JoJonium was published in Japan from December 4, 2013, to March 4, 2015. This edition covered the first three parts of the Jojo no Kimyou na Bouken series and included new cover art which showed redesigns of the characters by Araki Hirohiko. JoJonium's first three volumes cover the first part.

JoJo no Kimyou na Bouken Part 1: Phantom Blood was published in English by VIZ Media as JoJo's Bizarre Adventure Part 1: Phantom Blood under the Shonen Jump imprint digitally from September 2, 2014, to February 3, 2015, and in print from February 24, 2015, to August 4, 2015, featuring the JoJonium artwork and contents. It was also published in Italy by Star Comics from November 1993 to May 1994, and in Spain by Editorial Ivrea following the JoJonium format from June 30, 2017, to September 21, 2017.

A beat'em up video game based on the series developed by Namco Bandai Games Inc. was released in Japan on October 26, 2006.