Serge Battour is the son of a French viscount and a Romani prostitute, and despite his kind nature and academic talent, is shunned by his family and his peers due to the color of his skin. He begins to attend Lacombrade Academy, his father's alma mater, in the hopes that there he will find a place to belong.

Gilbert Cocteau is, like Serge, the orphaned son of a wealthy family, and is infamous at Lacombrade for his beautiful and delicate appearance, lack of dedication to schoolwork, and habit of prostituting himself to other students. He has no intention to connect with any of his classmates, instead devoting himself to his uncle Auguste.

Due to a shortage of living space, Serge and Gilbert become roommates even though Gilbert's antisocial nature has in the past made it impossible for him to room with anybody. Serge, being sociable and idealistic, is determined to be friends with Gilbert; Gilbert is only interested in either being able to manipulate Serge or push him away entirely. To the surprise of both of the boys, however, the two eventually form a deep, albeit generally dismal, bond that leads to a romantic connection.

Kaze to Ki no Uta won the 25th Shogakukan Manga Award in the Shoujo category in 1979. The series is considered to have popularized the boys' love genre and significantly contributed to its development.

The manga was published in Spanish by Milky Way Ediciones from August 29, 2018, to May 29, 2020; and in Italian by J-POP from December 19, 2018, to September 11, 2019.