Hoshi-sensei, a Japanese language teacher at an all-girls school, is at the mercy of his students and colleagues. Students challenge him to their shiritori word games illustrated in their daily notes, convince him to bring a dog into the classroom, and seek his advice on becoming a manga artist, while colleagues drag him along on their rounds to the pub. Matter-of-fact interactions between a cast of unique characters make for an offbeat comedy.

Onna no Sono no Hoshi ranked first and fifth in the 2021 and 2022 Kono Manga ga Sugoi! for the Female Readers division, respectively. The series was nominated for the Manga Taisho Award for three consecutive years from 2021 to 2023. In 2022, the manga won the Social Impact Award at the 25th Japan Media Arts Festival. It was nominated for the 47th and 49th Kodansha Manga Awards in the General category in 2023 and 2025, respectively.