To die by their own hand is the fate of the children inflicted with Morte. This rare disease does not discriminate based on class or country; it draws the best and the worst out of those afflicted, ultimately compelling them to commit suicide in their youth.

In a sinister orphanage known as Doceo, newcomer Sasha meets the beautiful Manon, a girl who frequently shows up covered in bruises. Convinced that the person responsible for these injuries is Manon's terrifying advisor, Doudou Claverie, Sasha devises a reckless plan to stop Doudou from ever coming near Manon again.

Elsewhere, young and disillusioned writer Dante Caggiano finds himself working at Hotel Gratia, a cheerful foster home for children diagnosed with Morte. But when death finally comes to Gratia's halls, Dante cannot shake off the feeling that this may have nothing to do with the disease at all.