Saya, the main character, lost her memory and has been living with her adopted family. Her everyday life seems quite normal, except that she eats a lot more than she actually needs. Then one day she meets a guy named Hagi in a park. She is told that he has been searching for her, for a long time. Since then, her normal life has changed completely.

A high school girl named Saya can not remember anything from her past. A handsome young man, Hagi, appears and something seems familiar about him. This girl is more than human with an ancient and mysterious past. She will hunt down and kill the monsters called Chiropterans.

Blood+ was published in English by Dark Horse from February 6, 2008 to February 11, 2009. A digital edition was also released by the same publisher from January 25, 2012 to April 11, 2012.