In an enormous steel labyrinth riddled with horrifying creatures, humanity is forced to isolate itself in small enclaves while living in constant fear of its annihilation. In this dystopia, only a strange young man known as Killy is brave enough to traverse its unforgiving territories.

Possessing superhuman strength and a rare Graviton Beam Emitter, Killy fights off bloodthirsty beasts and other fiendish forces in his desperate search for a human with the Net Terminal Gene—genetic information that holds the potential to restore the corrupt world.

The dark world of Blame! follows Killy as he meets new people, sheds more blood, and draws closer to finding the Net Terminal Gene. Through these exploits, the true nature of the world is slowly pieced together.