Shirayuki is Tanbarun's friendly neighborhood herbalist, whose unique red hair ends up drawing unwanted attention from the vain prince of Tanbarun, Raji Shenazard. Faced with the unattractive proposition to become his concubine, Shirayuki chops off her hair and flees the country overnight. In her journey deep into the forest, she encounters Zen Wistalia, the prince of the neighboring country of Clarines. When Zen takes a bite out of a poisoned apple that Prince Raji sends in order to recapture Shirayuki, she expertly uses the herbs at her disposal to cure him.

Together with Zen and his two friends, Kiki and Mitsuhide, Shirayuki travels to Clarines, where she aims to make a life for herself as an apothecary of the royal court. As Zen slowly begins to mean more to her than the prince of her new country, the two of them must learn to work together toward their respective dreams despite the difference in status.

Included one-shots: Volume 1: Hachigatsu no Shikisai (Colorful Seasons of August) Volume 2: Bokura wo Tsunaide. (Connect Us) Volume 13: Shizuku no Saki ni (Beyond the Drops) Volume 14: Natsuyasumi 00-nichime (00 Days of Summer Vacation)

Akagami no Shirayuki-hime has been published in English as Snow White with the Red Hair by VIZ Media under the Shojo Beat imprint since May 7, 2019.