When a mysterious light suddenly engulfs Earth, humanity is left petrified, frozen in stone. Thousands of years later, the world is teeming with vegetation, and forests have taken the places of cities that once stood proudly. One of the very first to emerge from their stone prison is Taiju Ooki, who finds that his good friend, a brilliant young scientist named Senkuu, has been preparing for his awakening. While Taiju wishes to save the girl he loves, Senkuu is determined to figure out the cause behind the strange phenomenon and restore the world to its former glory.

But when they free the infamously powerful Tsukasa Shishiou in order to gain an upper hand against the dangers in an unfamiliar world, they realize that their new comrade has other plans. Tsukasa sees their predicament as a chance to start over; free from the corruption and destruction wrought by technology, he will stop at nothing to achieve his goals. With both sides unable to see eye to eye, Senkuu and his devotion to science will clash with Tsukasa and his primal nature in what will truly be a battle of the ages.

Dr. Stone won the 64th Shogakukan Manga Award in the Shounen category in 2019. The manga ranked 17th in the 2020 Kono Manga ga Sugoi! for the Male Readers division. As a part of the JUMP START initiative, the first three chapters of the manga were published in English in VIZ Media's digital Weekly Shonen Jump on the same day as the Japanese release. After, the series was added to VIZ Media's Weekly Shonen Jump lineup, and it was also simulpub through MANGA Plus. The volumes were published in English by VIZ Media under the Shonen Jump imprint from September 4, 2018, to June 3, 2025. It has also been released in Brazilian Portuguese by Panini Comics since September 2018.