Busou Renkin is the story of the teenager Kazuki Mutou, who dies trying to save a girl who was being attacked by an eerie monster. The next morning, however, Kazuki is left wondering whether it was all a dream. Lo and behold, the girl, the monster, and his death are all real! The girl, Tokiko Tsumura, was actually trying to slay the homunculus (a beast that can take the form of humans, but whose main source of food is people), but Kazuki got in her way. To revive Kazuki, Tokiko replaces his heart with a "kakugane," an alchemic device that allows him to summon a lance with which to fight the monsters. It turns out that Tokiko is a member of Renkin Kenshi (Alchemist Soldiers)—an organization sworn to protect the world from the diabolical creatures. Soon, Kazuki joins Tokiko in her quest to terminate the sinister being that creates and controls the homunculus.

Included one-shot: Volume 10: Embalming: Dead Body and Bride

Busou Renkin was published in English as Buso Renkin by VIZ Media under the Shonen Jump imprint from August 1, 2006, to February 5, 2008. It was also released in Brazilian Portuguese by Editora JBC from July 2010 to May 2011.