Ryo Saeba is a "sweeper" in the city of Tokyo. His works as a trouble shooter, cleaning the streets of vermin, and helping out desperate people. Sometimes he's a bodyguard, sometimes he's an assassin, whatever Ryo does he does it well. In fact his only flaw is his hormones - he loves the ladies and sometimes turns into an idiot when he's near them. Thankfully he's got people like his partner Kaori Makimura to keep him in check.

City Hunter was partially published in English by Gutsoon! Entertainment, who published the first five volumes from June 18, 2003 to April 28, 2004. It has been published digitally in English by Coamix through Manga Hot. The volumes have been published by Abrams Books since September 23, 2025.

The series was adapted into a live action movie in 2024.