Ghost Talker's Daydream is tells the story of Misaki Saiki, a young woman with a troubled past, who is a professional dominatrix in one of Tokyo's most exclusive S&M clubs. However, her real money is something she likes even less than being a dominatrix. Ever since childhood, Misaki has had the ability to see and communicate with ghosts, and that talent is put to use by the Livelihood Protection Agency, who pairs Misaki with Souichirou Kadotake, a martial artist who happens to be deathly afraid of ghosts. Using her gifts, Misaki is able to help troubled departed spirits resolve what is troubling them and allow them to move on to the afterlife. If all that isn't odd enough, Misaki is an albino and a virgin.