The setting is lush Astraea Hill, where three famous all-girls schools are built. It's the first day of school, and the cherry blossoms are scattering to the ground. Nagisa meets Shizuma Hanazono, the top student in the school, and her breath is taken away by her beauty. But when Shizuma takes a liking to Nagisa, love and chaos soon follow...

Strawberry Panic! entered what was initially a short break following the 2007 February issue of Dengeki G's magazine. In the April issue it was announced that the series would be entering an indefinite hiatus from which it ultimately never returned, remaining unfinished at 14 chapters.

The volumes of the series were published in English by Seven Seas Entertainment from December 23, 2007, to March 18, 2008. An omnibus titled Strawberry Panic: The Complete Manga Collection, which also contained the two previously uncompiled chapters, was published on September 28, 2010.